You can either go ahead over WHM –> Exim Configuration Manager –> Apache SpamAssassin Options –> Apache SpamAssassin™: Forced Global ON set to ON

or simply touch a file:

 touch /etc/global_spamassassin_enable

Now you have got SpamAssassin enabled for all users with default score 5

The default 5 score can be overwritten over by a user via /home/USER/.spamassassin/user_prefs file

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