You seems got this error at Roundcube or Horde.

Here is explanation how it works:

Supposedly you’re trying to send message with an attachment file 44M

And you have the message_size_limit set in 50M as explained here

And you will not be able to send such message because attachments in a message are encoded by base64

It means your message will be by 30% bigger than expected, please see below calculation

44*0.30=57

You cannot send such message due to the limit in 50M, so you need either rise message_size_limit or upload and share your attachment to services like Gdrive/Dropbox/etc

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